NAD+ (Nicotinamide Adenine Dinucleotide) treatments have been gaining significant attention within the health and wellness world due to their purported benefits in promoting cellular health and delaying the effects of aging. NAD+ is a vital coenzyme present in all cells and plays a crucial role in the production of energy and the regulation of pivotal cellular processes. As we age, the levels of NAD+ in our bodies tend to decrease, leading to a decline in mitochondrial function, which is associated with aging and various diseases.

Scientific research on NAD+ treatments suggests that boosting NAD+ levels in the body can potentially reverse signs of aging and improve the health of cells. Treatments usually involve supplements, intravenous infusions, and dietary changes aimed at increasing NAD+ production or replenishing its levels. These approaches have been linked to improved muscle function, enhanced brain health, and increased metabolic activity. Moreover, NAD+ treatments may offer promising therapeutic potentials in managing conditions such as neurodegenerative diseases, heart diseases, and metabolic disorders. However, it's important to note that while initial studies are encouraging, further research is necessary to fully elucidate the long-term effects and efficacy of NAD+ therapies in clinical settings.

In addition to its role in promoting cellular health and delaying aging, NAD+ treatments have also been linked to potential improvements in mental health. Studies have shown that NAD+ levels play a critical role in brain function, with lower levels being associated with cognitive decline and mood disorders such as depression and anxiety.

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Does your brain ever start to feel foggy? What about trouble focusing? Can't fall asleep at night? Tired when you wake up in the morning? Feeling like you can't do the things like you used to do? Do you have extra weight that just won't come off no matter what you do? Are you losing ambition, aspiration, enthusiasm and disinterest in things you once loved? Do you wish you could hit a button to REBOOT your energy, focus, metabolism and rid your brain of addictions?

As you expose your body to stress and any other psychological, emotional and physically toxic environments, your cells must work harder to manage that stress and keep you going. And your cells need the proper fuel and nutrients. This fuel is called Nicotinamide Adenine Dinucleotide (NAD), which is an essential molecule found in every cell of your body. As you age the natural production of NAD declines, causing you to feel different.

NAD IV therapy restores your NAD levels providing you with a vital reset. Your mitochondria will be reset, and all the toxins will be removed from your cells. And if you are dealing with any type of addiction, this treatment has been proven to help you fight that addiction because it decreases symptoms of withdrawal by 80-90%. This treatment is also recognized for treating the long-term psychological well-being of chemotherapy, referred to as chemo-brain.

Studies:

1. Therapeutic potential of boosting NAD+ in aging and age-related diseases: Emerging evidence implicates that elevation of NAD+ levels may slow or even reverse the aspects of aging and also delay the progression of age-related diseases.
2. Role of Nicotinamide Adenine Dinucleotide and Related Precursors as Therapeutic Targets for Age-Related Degenerative Diseases: Rationale, Biochemistry, Pharmacokinetics, and Outcomes:  Recent studies have shown that enhancing NAD+ levels can profoundly reduce oxidative cell damage in catabolic tissue, including the brain. Therefore, promotion of intracellular NAD+ anabolism represents a promising therapeutic strategy for age-associated degenerative diseases in general, and is essential to the effective realization of multiple benefits of healthy sirtuin activity.
3. NAD + biosynthesis, aging, and disease:  Indeed, new studies have demonstrated the therapeutic potential of supplementing NAD + intermediates, such as nicotinamide mononucleotide and nicotinamide riboside, providing a proof of concept for the development of an effective anti-aging intervention.
4. Emerging potential benefits of modulating NAD+ metabolism in cardiovascular disease:  NAD+-related metabolites have promising therapeutic effects in cardiovascular disease.
5. Therapeutic potential of NAD-boosting molecules: the in vivo evidence: Nicotinamide adenine nucleotide (NAD+) has emerged as a key regulator of cellular processes that control the body’s response to stress. Rajman et al. discuss NAD boosters, small molecules that raise NAD+ levels, which are now considered to be highly promising for the treatment of multiple diseases and the potential extension of human lifespan.
6. The NAD Deficiency Diseases: Argues that oral nicotine acid therapy provides an effective biological treatment for addiction to both alcohol and opiate drugs when given in daily doses of 500 mg or more. It is also purported that there is considerable evidence that this same treatment is effective for other manifestations of the nicotinamide adenine dinucleotide (NAD) deficiency disease like anorexia nervosa, early diabetes mellitus, heart failure, essential hypertension, schizophrenia (substrate pellagra), and even the problems of predatory behavior such as crime and violence. The author hypothesizes that NAD and the endorphins are the only 2 physiological substances that bind the so-called opiate receptors in the brain, and since the development of agriculture, humans have been susceptible to what he calls the NAD deficiency diseases, through a partial adaptation to less meat in the diet. (PsycINFO Database Record (c) 2019 APA, all rights reserved)
7. Treatment with NAD(+) inhibited experimental autoimmune encephalomyelitis by activating AMPK/SIRT1 signaling pathway and modulating Th1/Th17 immune responses in mice. Nicotinamide adenine dinucleotide (NAD(+)) plays vital roles in mitochondrial functions, cellular energy metabolism and calcium homeostasis. In this study, we investigated the effect of NAD(+) administration for the treatment of experimental autoimmune encephalomyelitis (EAE) in C57BL/6 mice. EAE, a classical animal model of multiple sclerosis (MS), was induced by subcutaneous injection of myelin oligodendrocyteglycoprotein (MOG). The mice were treated with 250mg/kg (body weight) NAD(+) in PBS administered intraperitoneally once daily. We observed that NAD(+) treatment could lessen the severity of EAE. Additionally, NAD(+) treatment attenuated pathological injuries of EAE mice. We also found that the AMP-activated protein kinase (AMPK)/silent mating-type information regulation 2 homolog 1(SIRT1) pathway was activated in the NAD(+)-treated mice and NAD(+) treatment suppressed pro-inflammatory T cell responses. Our findings demonstrated that NAD(+) could be an effective and promising agent to treat multiple sclerosis and its effects on other autoimmune diseases should be explored.

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